The chairman of the e-Health board has resigned, but opposition parties say Health Minister David Caplan should also go.
Doctor Alan Hudson follows C-E-O Sarah Kramer out the door after she received a $314thousand payout.
The departures come after the agency awarded millions of dollars in untendered consulting contracts.
Meantime, the premier says government ministries and agencies will no longer be allowed to award contracts to consultants without a competitive bidding process.
Premier Dalton McGuinty made the changes as he moved to quash a growing scandal at eHealth.
He says the agency should not have awarded $5 million in untendered consulting contracts.